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Name:LY2157299
| Chemical structure | Code NO. |
MT0200 |
 |
Name |
LY2157299 |
Synonym |
LY-2157299, LY 2157299 | |
CAS NO. |
700874-72-2 | |
Chemical Formula |
C22H19N5O | |
MW |
369.42 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO 74 mg/ml Water <1 mg/ml Ethanol <1 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
|
Size |
Price |
Availability |
|
1g |
$280 |
In stock |
|
5g |
$1300 |
In stock |
|
10g |
$1900 |
In stock |
|
>10g |
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In stock |
|
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Description
LY2157299 is a new type I receptor TGF-beta kinase inhibitor. LY-2157299 could inhibit TGF-beta-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells. In vivo administration of LY-2157299 ameliorated anemia in a TGF-beta overexpressing transgenic mouse model of bone marrow failure. Treatment with LY-2157199 stimulated hematopoiesis from primay MDS bone marrow specimens.
References
[1] Eur J Cancer 44(1): 142-150.
Attention
Sold for research purposes only; not for human, medical, veterinary, food or household use.
