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Name: A-966492
| Chemical structure | Code NO. |
MT0634 |
 |
Name |
A-966492 |
Synonym |
N/A | |
CAS NO. |
934162-61-5 | |
Chemical Formula |
C18H17FN4O | |
MW |
324.35 | |
Purity |
99% | |
Solubility(R.T.: 25℃) |
DSMO 65 mg/ml Water <1 mg/ml Ethanol <1 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
|
Size |
Price |
Availability |
|
100 mg |
$380 |
In stock |
|
250 mg |
$500 |
In stock |
|
1 g |
$980 |
In stock |
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
A-966492 is one of the most potent PARP inhibitors. A-966492 displays excellent potency against the PARP-1 enzyme with a Kiof 1 nM.
A-966492 shows good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin. In vivo, A-966492 demonstrates significant enhancement of the efficacy of TMZ in a murine B16F10 syngeneic melanoma model, with the A-966492 combination groups showing superior efficacy.
References
[1] Penning TD, et al."Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor." J Med Chem, 2010, 53(8), 3142-53.
Attention
Sold for research purposes only; not for human use of any kind.
