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Name:WDR5-0103
| Chemical structure | Code NO. |
MT1113 |
 |
Name |
WDR5-0103 |
Synonym |
WD-Repeat Protein 5-0103 | |
CAS NO. |
890190-22-4 | |
Chemical Formula |
C21H25N3O4 | |
MW |
383.44 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO:40mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
|
Size |
Price |
Availability |
|
100mg |
$280 |
In stock |
|
250mg |
$560 |
In stock |
|
1g |
$780 |
In stock |
|
>1g |
Get quote |
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|
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Description
WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.
IC50 value: 450 nM (Kd)
Target: WDR5
in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.
IC50 value: 450 nM (Kd)
Target: WDR5
in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5.
References
Attention
Sold for research purposes only; not for human use of any kind.
