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Name:ZM241385
| Chemical structure | Code NO. |
MT1165 |
 |
Name |
ZM241385 |
Synonym |
ZM-241385; ZM 241385 | |
CAS NO. |
139180-30-6 | |
Chemical Formula |
C16H15N7O2 | |
MW |
337.34 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO: ＞ 34 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
|
Size |
Price |
Availability |
|
100mg |
$650 |
In stock |
|
500mg |
$900 |
In stock |
|
1g |
$1300 |
In stock |
|
>1g |
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In stock |
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Description
ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.
Target: adenosine receptor
in vitro: ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. [1]
in vivo: ZM 241385 has low potency at A2b receptors and antagonized the relaxant effects of adenosine in the guinea-pig aorta. ZM 241385 has a low affinity at A1 receptors. In rat cerebral cortex membranes it displaces tritiated R-phenylisopropyladenosine (R-PIA) with a pIC50 of 5.69. [2]
Target: adenosine receptor
in vitro: ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. [1]
in vivo: ZM 241385 has low potency at A2b receptors and antagonized the relaxant effects of adenosine in the guinea-pig aorta. ZM 241385 has a low affinity at A1 receptors. In rat cerebral cortex membranes it displaces tritiated R-phenylisopropyladenosine (R-PIA) with a pIC50 of 5.69. [2]
References
Attention
Sold for research purposes only; not for human use of any kind.
