Location : Home > Products > Inhibitors of Meditech > GPCR & G Protein > CaSR
Name:NPS-2143
| Chemical structure | Code NO. |
MT1029 |
 |
Name |
NPS-2143 |
Synonym |
NPS 2143; SB 262470A; NPS2143 | |
CAS NO. |
284035-33-2; 324523-20-8(HCl) | |
Chemical Formula |
C24H25ClN2O2 | |
MW |
408.92 | |
Purity |
99% | |
Solubility(R.T.: 25℃) |
DMSO 82 mg/ml,Water <1 mg/ml,Ethanol <1 mg/ml | |
Stability |
- |
Availability and price
|
Size |
Price |
Availability |
|
100 mg |
$390 |
In stock |
|
250 mg |
$450 |
In stock |
|
1 g |
$750 |
In stock |
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. [1] NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation. [1] In HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH (data not shown) and gamma-Glu-Val-Gly. [3] A recent study shows that NPS 2143 treatment suppresses low molecular weight fractions of azuki hydrolysate-induced cholecystokinin (CCK) secretion in CaSR-transfected HEK 293 cells.
References
Attention
Sold for research purposes only; not for human use of any kind.
