Location : Home > Products > Inhibitors of Meditech > Others > others
Name:Mitomycin C
| Chemical structure | Code NO. |
MT1155 |
 |
Name |
Mitomycin C |
Synonym |
Ametycine | |
CAS NO. |
50-07-7 | |
Chemical Formula |
C15H18N4O5 | |
MW |
334.33 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO > 30 mg/ml | |
Stability |
-20℃，2 years |
Availability and price
|
Size |
Price |
Availability |
|
1g |
$280 |
In stock |
|
5g |
$1250 |
In stock |
|
>5g |
Get quote |
In stock |
|
We match the best price and quality on market! | ||
Quality Control: 1.Mitomycin C-HNMR.pdf 2.Mitomycin C-HPLC.pdf
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
IC50 Value: 0.14 μM (EC50, Cytotoxicity against PC3 cells )
Target: DNA alkylator; ADCs toxin
Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent making it useful as an antibiotic antitumor product. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.
IC50 Value: 0.14 μM (EC50, Cytotoxicity against PC3 cells )
Target: DNA alkylator; ADCs toxin
Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent making it useful as an antibiotic antitumor product. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.
References
Attention
Sold for research purposes only; not for human use of any kind.
