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Name:DMOG
| Chemical structure | Code NO. |
MT0694 |
 |
Name |
DMOG |
Synonym |
Dimethyloxallyl Glycine | |
CAS NO. |
89464-63-1 | |
Chemical Formula |
C6H9NO5 | |
MW |
175.14 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
water:>30 mg/ml ;DMSO: >25 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
DMOG is in stock. Bulk available at low price, welcom to inquire quotation.
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1α prolyl hydroxylase).
IC50 value:
Target: HIF-1α prolyl hydroxylase
The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.
IC50 value:
Target: HIF-1α prolyl hydroxylase
The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.
References
Attention
Sold for research purposes only; not for human use of any kind.
