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Name:BMS-707035
| Chemical structure | Code NO. |
MT1033 |
 |
Name |
BMS-707035 |
Synonym |
BMS 707035; BMS707035 | |
CAS NO. |
729607-74-3 | |
Chemical Formula |
C17H19FN4O5S | |
MW |
410.42 | |
Purity |
99% | |
Solubility(R.T.: 25℃) |
DMSO ≥35mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL | |
Stability |
- 20℃, 2 years |
Availability and price
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Description
BMS-707035 is a pyrimidine carboxamide similar to Raltegravir, the first integrase inhibitor licensed for clinical use. BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM.
References
[1] [1] Dicker IB, et al."Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors." J Biol Chem, 2007, 282(43), 31186-31196.
[2] [2] Langley DR, et al."The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors." Biochemistry, 2008, 47(51), 13481-13488.
[2] [2] Langley DR, et al."The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors." Biochemistry, 2008, 47(51), 13481-13488.
Attention
