Location : Home > Products > Inhibitors of Meditech > PI3K/mTOR/AKT > Akt
Name:AKT inhibitor VIII
| Chemical structure | Code NO. |
MT0820 |
 |
Name |
AKT inhibitor VIII |
Synonym |
||
CAS NO. |
612847-09-3 | |
Chemical Formula |
C34H29N7O | |
MW |
551.64 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
10 mM in DMSO | |
Stability |
- 20℃, 2 years |
Availability and price
AKT inhibitor VIII is in stock. Bulk available at low price, welcom to inquire quotation.
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively).
IC50 value: 58/210/2120 nM(Akt1/2/3)
Target: Akt
Akt Inhibitor VIII does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.
IC50 value: 58/210/2120 nM(Akt1/2/3)
Target: Akt
Akt Inhibitor VIII does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.
References
Attention
Sold for research purposes only; not for human use of any kind.
