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Name:E-3810
| Chemical structure | Code NO. |
MT1071 |
 |
Name |
E-3810 |
Synonym |
E 3810; E3810; Lucitanib | |
CAS NO. |
1058137-23-7 | |
Chemical Formula |
C26H25N3O4 | |
MW |
443.49 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
10 mM in DMSO | |
Stability |
- 20℃, 2 years |
Availability and price
We offer big discount for bulk quantities. If you have any other questions or needs, please send email to sales@meditechbs.com. We’ll reply you asap.
Description
E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity.
IC50 value:
Target: VEGFR/FGFR
VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
IC50 value:
Target: VEGFR/FGFR
VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.
References
[2]. Study of Oral E-3810, a Dual VEGFR-FGFR Tyrosine Kinase Inhibitor, in Patients With Solid Tumors.
Attention
Sold for research purposes only; not for human use of any kind.
