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Name:Z-VAD-FMK
| Chemical structure | Code NO. |
MT1151 |
 |
Name |
Z-VAD-FMK |
Synonym |
Z-VAD(OMe)-FMK; Z-Val-Ala-Asp(OMe)-FMK | |
CAS NO. |
187389-52-2 | |
Chemical Formula |
C22H30FN3O7 | |
MW |
467.49 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO 90 mg/ml; Water <1 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
|
Size |
Price |
Availability |
|
100mg |
$980 |
In stock |
|
250mg |
$1760 |
In stock |
|
1g |
$3900 |
In stock |
|
>1g |
Get quote |
Get quote |
|
We match the best price and quality on market! | ||
Quality Control: 1.Z-VAD-FMK-HNMR.pdf
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Description
Z-VAD-FMK is a cell-permeable, irreversible broad-spectrum caspase inhibitor, blocks all features of apoptosis.
IC50 value:
Target: Caspase
in vitro: Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells [1]. Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells [2]. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells [3].
IC50 value:
Target: Caspase
in vitro: Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells [1]. Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells [2]. Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells [3].
References
Attention
Sold for research purposes only; not for human use of any kind.
