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Name:PF 477736
Chemical structure | Code NO. |
MT1137 |
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Name |
PF 477736 |
Synonym |
PF-0044736; PF0044736; PF477736; PF-477736 | |
CAS NO. |
952021-60-2 | |
Chemical Formula |
C22H25N7O2 | |
MW |
419.48 | |
Purity |
>98% | |
Solubility(R.T.: 25℃) |
DMSO: 6 mg/mL, H2O: <1 mg/ml | |
Stability |
- 20℃, 2 years |
Availability and price
Size |
Price |
Availability |
100mg |
$380 |
In stock |
250mg |
$740 |
In stock |
1g |
$1180 |
In stock |
>1g |
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Description
PF 477736 is a CHK inhitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity
References
[2]. S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.
Attention
Sold for research purposes only; not for human use of any kind.